Isaac Minde has worked on many aspects of agricultural development in Africa through his long term assignments in Rwanda, Malawi, Uganda, Zimbabwe and South Africa. He has held positions in the Tanzanian government as district agricultural development officer, academic staff member in the University of Dar es Salaam and Sokoine University of Agriculture—where in the latter he served as chair of the agricultural economics department.

He has worked in the sub-regional agricultural research organization (ASARECA), and the Consultative Group on International Agricultural Research (CGIAR)–IITA and later with ICRISAT as Principal Scientist and Head of the ICRISAT Diplomatic Mission in Zimbabwe. Through these engagements, Dr. Minde has the working knowledge of the regional political and economic blocs of COMESA, EAC and SADC in eastern and southern Africa. He then joined Michigan State University, where among others, is the Deputy Director of iAGRI in Tanzania. Within iAGRI, Dr. Minde supervises long term training and collaborative research activities, among others.